Prof Neil O'Brien-Simpson
Program Leader
Melbourne Dental School
University of Melbourne
neil.obs@unimelb.edu.au
Research Activities
- Host repsonse to bacterial outer membrane vesicles (OMVs)
- Vaccine design and development - synthetic peptides and recombinant proteins
- Evaluation of the host response to bacterial oral infection
- Role of γδT cells, NKT cells and innate immune cells in bacterial oral infection
- Antimicrobial peptide development.
- Nanomaterials for vaccine delivery.
- Nanomaterials as antimicrobial compounds
Techniques/Expertise
- Peptide synthesis and modification, HPLC etc.
- Nanomaterial fabrication
- Flow cytometry, Bioplex, MACS and FACS sorting, T cell proliferation, cytokine assays (ELISPOT, Bioplex), cell culture (T cells and subsets, B cells, macrophages, epithelial, endothelial etc)
Collaborations
Prof John Wade (Howard Florey Institute)Prof Greg Qiao (Dept Engineering, University of Melbourne)
Dr Maria Liaskos
Prof Frances Separovic
Prof Stuart Dashper
Prof Andrea O'Connor (Dept Biomedical Engineering, University of Melbourne)
Disease Models
Bacterial induced bone lossbacterial induced peritonitis
Sepsis
Genetically Modified Organisms
αβ-TCR-/-, γδTCR-/-, IL-4-/-, IL-13-/-Other Lab Members
Dr Jason LenzoDr James Holden
Mr William Singleton
Dr Alexis Gonzalez
Dr Sara Hadjigol
