Dr Seth Masters
Laboratory Head
Inflammation Division
Walter and Eliza Hall Institute of Medical Research
seth.masters@hudson.org.au
Research Activities
Research in the Masters lab is focused on inflammation from the innate immune system. This can happen in many different contexts, for example during a bacterial or virus infection; when cells die during an organ or tissue transplant; or when genetic mutations activate innate immune pathways. The innate immune response is also fundamentally involved in the pathogenesis of many chronic inflammatory diseases like inflammatory bowel disease, type 2 diabetes, and neuroinflammatory conditions.Techniques/Expertise
Inflammasome activationNon apoptotic cell death, eg Pyroptosis and Necroptosis
CRISPR
Collaborations
Prof Luke O'Neill (Trinity College Dublin)Dr Daniel Kastner (NIH)
Disease Models
Genetic autoinflammatory diseaseInfections (Toxo, LCMV, Listeria)
Inflammatory bowel disease
Type 2 diabetes
Neuroinflammation
Genetically Modified Organisms
Inflammasome activation mice (NLRP1 and NLRP3)Inflammasome deficient mice (many eg. Caspase-1, ASC, NLRP3)
Mice lacking cell death genes (many eg Caspase-11)
Other Lab Members
Senior Postdoctoral Fellow:Motti Gerlic, BSc, PhD Israel
Postdoctoral Fellow:
Man Lyang Kim, BSc, MSc South Korea, PhD Basel
Postgraduate Student:
Paul Baker, BSc(Hons) Adelaide
Undergraduate Student:
Damian D'Silva, BSc RMIT
Katelyn Chalker, BSc Uni Queensland
